Prof Moherndran Archary

Prof Moherndran Archary

Person Prof Moherndran Archary
Designation Paediatric Infectious Disease Specialist / Senior Specialist
Telephone +27(0)31 260 4318
Email archary@ukzn.ac.za
Campus NRMSM
Research interest Paediatric TB and HIV therapeutics
Biosketch  Prof Archary is an Honorary Associate Professor in the School of Clinical Medicine and a Paediatric Infectious Disease Specialist in the Department of Paediatrics and Child Health at the University of KwaZulu-Natal/King Edward VIII Hospital. Prof Archary specialises in the management of children with infectious diseases in resource-limited settings. As part of his PhD thesis, he investigated the pharmacokinetics of antiretroviral drugs in severely malnourished HIV infected children. His research interests include antiretroviral and antituberculosis drug therapeutics, drug resistance, and the optimal timing of antiretroviral therapy initiation in the developing world. He serves on several local, national and international committees.
  SELECTED PUBLICATIONS 

https://www.ncbi.nlm.nih.gov/myncbi/1b5aZG3sziGkm/bibliography/54050291/public/ 

Peer-reviewed journal articles (three years)

  1. Jassat W, Cohen C, Tempia S, Masha M, Goldstein S, Kufa T, et al.; DATCOV author group. Risk factors for COVID-19-related in-hospital mortality in a high HIV and tuberculosis prevalence setting in South Africa: a cohort study. Lancet HIV. 2021 Sep;8(9):e554-e567. doi: 10.1016/S2352-3018(21)00151-X. Epub 2021 Aug 4. PMID: 34363789; PMCID: PMC8336996.
  2. Jassat W, Mudara C, Ozougwu L, Tempia S, Blumberg L, Davies MA, et al.; DATCOV author group. Difference in mortality among individuals admitted to hospital with COVID-19 during the first and second waves in South Africa: a cohort study. Lancet Glob Health. 2021 Sep;9(9):e1216-e1225. doi: 10.1016/S2214-109X(21)00289-8. Epub 2021 Jul 9. PMID: 34252381; PMCID: PMC8270522.
  3. Millar JR, Fatti I, Mchunu N, Bengu N, Grayson NE, … Archary M, … Goulder P. Second-generation mother-to-child HIV transmission in South Africa is characterized by poor outcomes. AIDS. 2021 Aug 1;35(10):1597-1604. doi: 10.1097/QAD.0000000000002915. PMID: 34270488.
  4. Archary M, van Zyl R, Sipambo N, Sorour G. Optimised paediatric antiretroviral treatment to achieve the 95-95-95 goals. SAfr J HIV Med. 2021;22(1):1-4. doi:https://doi.org/10.4102/sajhivmed.v22i1.1278
  5. Olomukoro CN, Dlova NC, Sibanda W, Chateau AV, Archary M, Mosam A. Mucocutaneous diseases in the combined antiretroviral therapy era: prevalence and spectrum in HIV seropositive children and adolescents in Durban, South Africa. Int J Dermatol. 2021 Jul 26. doi: 10.1111/ijd.15735. Epub ahead of print. PMID: 34310691.
  6. Tikiso T, McIlleron H, Burger D, Gibb D, Rabie H, Lee J, Lallemant M, Cotton MF, Archary M, Hennig S, Denti P. Abacavir pharmacokinetics in African children living with HIV: a pooled analysis describing the effects of age, malnutrition and common concomitant medications. Br J Clin Pharmacol. 2021 Jul 14. doi: 10.1111/bcp.14984. Epub ahead of print. PMID: 34260082.
  7. Zanoni BC, Archary M, Sibaya T, Musinguzi N, Kelley ME, McManus S, Haberer JE. Development and validation of the HIV adolescent readiness for transition scale (HARTS) in South Africa. J Int AIDS Soc. 2021 Jul;24(7):e25767. doi: 10.1002/jia2.25767. PMID: 34235876.
  8. Marume A, Archary M, Mahomed S. Validation of growth standards and growth references: A review of literature. J Child Health Care. 2021 Jun 11:13674935211024816. doi: 10.1177/13674935211024816. Epub ahead of print. PMID: 34114485.
  9. Millar JR, Bengu N, Vieira VA, Adland E, Roider J, Muenchhoff M, …, Archary M, …, Goulder P. Early initiation of antiretroviral therapy following in utero HIV infection is associated with low viral reservoirs but other factors determine subsequent plasma viral rebound. J Infect Dis. 2021 May 8: jiab223. doi: 10.1093/infdis/jiab223. Epub ahead of print. PMID: 33963757.
  10. Shinde V, Bhikha S, Hoosain Z, Archary M, Bhorat Q, Fairlie L, et al.; 2019nCoV-501 Study Group. Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant. N Engl J Med. 2021 May 5. doi: 10.1056/NEJMoa2103055. Epub ahead of print. PMID: 33951374.
  11. Cele S, Gazy I, Jackson L, Hwa SH, Tegally H, Lustig G, et al.; Network for Genomic Surveillance in South Africa; COMMIT-KZN Team, Lessells RJ, de Oliveira T, Sigal A. Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma. Nature. 2021 May;593(7857):142-146. doi: 10.1038/s41586-021-03471-w. Epub 2021 Mar 29. PMID: 33780970.
  12. Archary M, Sartorius B, La Russa P, Sibaya T, Healy M, Bobat RA. Effect of the Timing of Antiretroviral Treatment Initiation on Outcomes in Children Living With Human Immunodeficiency Virus Admitted With Severe Acute Malnutrition. J Pediatric Infect Dis Soc. 2021 Apr 3;10(3):259-266. doi: 10.1093/jpids/piaa054. PMID: 32469406; PMCID: PMC8023316.
  13. Pillay K, Lewis L, Rambaran S, Yende-Zuma N, Archary D, Gengiah S, Govender D, Hassan-Moosa R, Samsunder N, Abdool Karim SS, McKinnon LR, Padayatchi N, Naidoo K, Sivro A. Plasma Biomarkers of Risk of Tuberculosis Recurrence in HIV Co-Infected Patients From South Africa. Front Immunol. 2021 Mar 25;12:631094. doi: 10.3389/fimmu.2021.631094. PMID: 33841412; PMCID: PMC8026888.
  14. Zanoni BC, Archary M, Subramony T, Sibaya T, Psaros C, Haberer JE. ‘It was not okay because you leave your friends behind’: A prospective analysis of transition to adult care for adolescents living with perinatally-acquired HIV in South Africa. Vulnerable Children and Youth Studies. 2021. doi: 10.1080/17450128.2021.1876965
  15. Zanoni BC, Archary M, Subramony T, Sibaya T, Psaros C, Haberer JE. Disclosure, Social Support, and Mental Health are Modifiable Factors Affecting Engagement in Care of Perinatally-HIV Infected Adolescents: A Qualitative Dyadic Analysis. AIDS Behav. 2021 Jan;25(1):237-248. doi: 10.1007/s10461-020-02968-1. PMID: 32638220; PMCID: PMC7790871.
  16. Moore CL, Turkova A, Mujuru H, Kekitiinwa A, Lugemwa A, Kityo CM, …, Archary M, …, Ford D; ODYSSEY Trial Team. ODYSSEY clinical trial design: a randomised global study to evaluate the efficacy and safety of dolutegravir-based antiretroviral therapy in HIV-positive children, with nested pharmacokinetic sub-studies to evaluate pragmatic WHO-weight-band based dolutegravir dosing. BMC Infect Dis. 2021 Jan 4;21(1):5. doi: 10.1186/s12879-020-05672-6. PMID: 33446115; PMCID: PMC7809782.
  17. Misser SK, Barkovich AJ, Lotz JW, Archary M. A pictorial review of the pathophysiology and classification of the magnetic resonance imaging patterns of perinatal term hypoxic ischemic brain injury – What the radiologist needs to know…. SA J Radiol. 2020 Oct 30;24(1):1915. doi: 10.4102/sajr.v24i1.1915. PMID: 33240541; PMCID: PMC7670012.
  18. Archary M, Mngqibisa R. Oral PrEP in adolescents in sub-Saharan Africa. Lancet Child Adolesc Health. 2020 Dec;4(12):854-855. doi: 10.1016/S2352-4642(20)30340-0. Epub 2020 Oct 24. PMID: 33222801.
  19. Zanoni BC, Archary M, Sibaya T, Musinguzi N, Haberer JE. Transition from pediatric to adult care for adolescents living with HIV in South Africa: A natural experiment and survival analysis. PLoS One. 2020 Oct 27;15(10):e0240918. doi: 10.1371/journal.pone.0240918.
  20. Smith AM, Tau NP, Ngomane HM, Sekwadi P, Ramalwa N, Moodley K, …, Archary M, Thomas J. Whole-genome sequencing to investigate two concurrent outbreaks of Salmonella Enteritidis in South Africa, 2018. J Med Microbiol. 2020 Oct 13. doi: 10.1099/jmm.0.001255.
  21. Archary M, Pettifor AE, Toska E. Adolescents and young people at the centre: global perspectives and approaches to transform HIV testing, treatment and care. J Int AIDS Soc. 2020 Sep;23 Suppl 5:e25581. doi: 10.1002/jia2.25581.
  22. Jacobs TG, Svensson EM, Musiime V, Rojo P, Dooley KE, McIlleron H, et al.; WHO Paediatric Antiretroviral Working Group. Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV/TB co-infection: a systematic review. J Antimicrob Chemother. 2020 Aug 12:dkaa328. doi: 10.1093/jac/dkaa328. Epub ahead of print.
  23. Kalawan V, Naidoo K, Archary M. Impact of routine birth early infant diagnosis on neonatal HIV treatment cascade in eThekwini district, South Africa. South Afr J HIV Med. 2020 Jun 2;21(1):1084. doi: 10.4102/sajhivmed.v21i1.1084.
  24. Millar JR, Bengu N, Fillis R, Sprenger K, Ntlantsana V, Vieira VA, …, Archary M, …, Goulder P; Ucwaningo Lwabantwana Consortium. HIGH-FREQUENCY failure of combination antiretroviral therapy in paediatric HIV infection is associated with unmet maternal needs causing maternal NON-ADHERENCE. EClinicalMedicine. 2020 May 8;22:100344. doi: 10.1016/j.eclinm.2020.100344.
  25. Archary M, Sartorius B, La Russa P, Sibaya T, Healy M, Bobat RA. Effect of the Timing of Antiretroviral Treatment Initiation on Outcomes in Children Living With Human Immunodeficiency Virus Admitted With Severe Acute Malnutrition. J Pediatric Infect Dis Soc. 2020 May 29:piaa054. doi: 10.1093/jpids/piaa054.
  26. Adland E, Millar J, Bengu N, Muenchhoff M, Fillis R, Sprenger K, et al. Sex-specific innate immune selection of HIV-1 in utero is associated with increased female susceptibility to infection. Nat Commun. 2020 Apr 14;11(1):1767. doi: 10.1038/s41467-020-15632-y.
  27. Zuma P, Ramsamy Y, Mlisana K, Archary M. Serum Cryptococcal Antigen Testing in Immunosuppressed HIV-positive Children and Adolescents. Pediatr Infect Dis J. 2020 Mar;39(3):217-220. doi: 10.1097/INF.0000000000002538.
  28. Kubheka SE, Archary M, Naidu KK. HIV viral load testing coverage and timeliness after implementation of the wellness anniversary in a paediatric and adolescent HIV clinic in KwaZulu-Natal, South Africa. South Afr J HIV Med. 2020 Feb 3;21(1):1016. doi: 10.4102/sajhivmed.v21i1.1016. eCollection 2020.
  29. Archary M, Zanoni B, Lallemant M, Suwannaprom P, Clarke D, Penazzato M. Acceptability and Feasibility of Using Raltegravir Oral Granules for the Treatment of Neonates in a Low-resource Setting. Pediatr Infect Dis J. 2020 Jan;39(1):57-60. doi: 10.1097/INF.0000000000002539.
  30. Archary M, Fairlie L, Slogrove A. Current perspectives on paediatric HIV management from the Mexico International Aids Society Conference, 2019. South Afr J HIV Med. 2019 Oct 31;20(1):1027. doi: 10.4102/sajhivmed.v20i1.1027.
  31. Cele MA, Archary M. Acceptability of short text messages to support treatment adherence among adolescents living with HIV in a rural and urban clinic in KwaZulu-Natal. South Afr J HIV Med. 2019 Oct 3;20(1):976. doi: 10.4102/sajhivmed.v20i1.976.
  32. Penazzato M, Townsend CL, Rakhmanina N, Cheng Y, Archary M, Cressey TR, et al.; PADO4 participants. Prioritising the most needed paediatric antiretroviral formulations: the PADO4 list. Lancet HIV. 2019 Sep;6(9):e623-e631. doi: 10.1016/S2352-3018(19)30193-6.
  33. Archary M, Mcllleron H, Bobat R, LaRussa P, Sibaya T, Wiesner L, et al. Population pharmacokinetics of abacavir and lamivudine in severely malnourished human immunodeficiency virus-infected children in relation to treatment outcomes. Journal British Journal of Clinical Pharmacology. 2019:85:2066-2075. doi: 10.1111/bcp.
  34. Millar JR, Mvo Z, Bengu N, Fillis R, Sprenger K, Matthews PC, Archary M, et al.; Ucwaningo Lwabantwana Consortium Group. Increasing Diagnostic Uncertainties in Children With In Utero HIV Infection. Pediatr Infect Dis J. 2019 Aug;38(8):e166-e168. doi: 10.1097/INF.0000000000002315.
  35. Nachman S, Townsend CL, Abrams EJ, Archary M, Capparelli E, Clayden P, et al. Long-acting or extended-release antiretroviral products for HIV treatment and prevention in infants, children, adolescents, and pregnant and breastfeeding women: knowledge gaps and research priorities. Lancet HIV. 2019 Aug;6(8):e552-e558. doi: 10.1016/S2352-3018(19)30147-X.
  36. Smith S, Govender K, Moodley P, La Russa P, Kuhn L, Archary M. Impact of Shifts to Birth Testing on Early Infant Diagnosis Program Outcomes in KwaZulu-Natal, South Africa. Pediatr Infect Dis J. 2019 Jul;38(7):e138-e142. doi: 10.1097/INF.0000000000002341
  37. Ngwenya N, Ambler J, Archary M. Qualitative situational analysis of palliative care for adolescents with cancer and HIV in South Africa: healthcare worker perceptions. BMJ Open. 2019 Jan 25;9(1):e023225. doi: 10.1136/bmjopen-2018-023225.
  38. Abrams EJ, Ananworanich J, Archary M, Ngongondo M, Brouwers P. Propelling the Pediatric HIV Therapeutic Agenda With Science, Innovation, and Collaboration. J Acquir Immune Defic Syndr. 2018 Aug 15;78 Suppl 1:S32-S39. doi: 10.1097/QAI.0000000000001747.
  39. Mvo Z, Ntlantsana V, Bengu N, Millar J, Roider J, Bhoola R, et al. Unmet needs of high-risk mothers reduce success of antiretroviral treatment in HIV-infected infants. S Afr Med J. 2018 Jul 25;108(8):609-610. doi: 10.7196/SAMJ.2018.v108i8.13376.
  40. Archary M, McLlleron H, Bobat R, Russa P, Sibaya T, Wiesner L, Hennig S. Population Pharmacokinetics of Lopinavir in Severely Malnourished HIV-infected Children and the Effect on Treatment Outcomes. Pediatric Infectious Disease Journal. 2018; 37:349-355. Doi: 10.1097/INF.0000000000001867.
  41. Mahomed S, Archary M, Mutevedzi P, Mahabeer Y, Govender P, Ntshoe G, et al. An isolated outbreak of diphtheria in South Africa, 2015 – Erratum. Epidemiol Infect. 2018 Apr;146(5):664. doi: 10.1017/S0950268817001376.
  42. Frigati L, Archary M, Rabie H, Penazzato M, Ford N. Priorities for Decreasing Morbidity and Mortality in Children With Advanced HIV Disease. Clin Infect Dis. 2018 Mar 4;66(suppl_2):S147-S151. doi: 10.1093/cid/ciy013.
  43. Angelidou K, Palumbo P, Lindsey J, Violary A, Archary M, Barlow L, et al.; International Maternal Pediatric Adolescent AIDS Clinical Trials Group (IMPAACT) P1060 Study Team. Defining Study Outcomes That Better Reflect Individual Response to Treatment. Pediatr Infect Dis J. 2018 Mar;37(3):258-262. doi: 10.1097/INF.0000000000001766

Muenchhoff M, Healy M, Singh R, Roider J, Groll A, Kindra C, Sibaya T, Moonsamy A, McGregor C, Phan M, Palma A, Kloverpris H, Leslie A, Bobat R, Larussa P, NdungU T, Goulder P, Sobieszczyk M, Archary M. Malnutrition in HIV-Infected Children Is an Indicator of Severe Disease with an Impaired Response to Antiretroviral Therapy. AIDS Research and Human Retroviruses. 2018; 34:46-55. DOI 10.1089/aid.2016.0261. ISSN/ISBN Number 19318405