Prof PM Jeena
Professor PM Jeena
Nelson R Mandela School of Medicine
HIV, TB, cmv, and ALRI
Head PICU and pulmonology
|Biosketch|| A. Personal statement
I have extensive research experience in several areas of Human immunodeficiency virus research; including being the first to describe pneumocystis jirovecii and cytomegalovirus pneumonia in HIV infected African children. For nearly 20 years my work has focused on acute and chronic lung infections in HIV infected children and we are currently completing data analysis on the pathogenic role of Cytomegalovirus disease and infection among children admitted to the ICU with very severe pneumonia. I have worked with Dr Bruce Walker and Dr Philip Goulder on cytotoxic T Cell assays amongst HIV infected children and we evaluated the role of structured treatment interruption of antiretroviral therapy among HIV infected infants. I have also been involved with work on the environmental risk factors for transmission, the pathogenic characteristic and cytokine responses among children infected with mycobacterium tuberculosis. A manuscript on the pharmacodynamics and pharmacokinectics of first line anti-tuberculosis agents among children with symptomatic Mtb has been for publications.
These experiences and accomplishments have resulted in my being named Director of the Paediatric Critical Care Unit and Head of Paediatric Pulmonology in Durban, South Africa. I also served as Chair of the Essential Drugs Program for Children in South Africa and a member of the South African National Aids Council. I have serve as an independent expert to International Union against tuberculosis and lung disease on the care of HIV infected children with tuberculosis and a member of the advisory committee of WHO on acute respiratory infections.
I am clinical researcher whose main research area involves clinical issues. This application provides me with an excellent platform to collaborate with basic science researchers from the USA, the Africa centre as well as other clinical specialties i.e. obstetricians and neonatologists. The current research proposal would extend my own passion to creating an understanding of the pathogenic mechanism involved in the birectional relationship between HIV and CMV infections. Understanding this might provide the key for reducing the transmission of both pathogens. Evaluation risk factors for transmission of these pathogens and the impact of antiviral agents would be most useful. Most importantly studying the role of CMV infection/disease among HIV exposed but uninfected children will be extremely important as this group of cases would carry the bulk of the burden of disease as we improve prevention of mother to transmission of HIV infection.
The burden of HIV infection in the area drained by the Prince Mysheni Memorial Hospital is substantial and given that there is an NIH research site at this venue, we would be able to recruit the patients require number to complete this study. Obtaining an adequate and relevant history among mother who have recently delivered a baby would be possible after informed consent is obtained. The taking of blood and saliva samples for the molecular recognition and measurement of CMV loads at birth or soon tghereafter (first 4 days) would be feasible. Follow up of enrolled cases would be possible given that the site has been involved in previous studies where follow up rates have exceeded 90%. Data from the proposed study, would be useful to expand knowledge on the concepts of burden of CMV INFECTION/DISEASE among HIV infected, exposed uninfected and uninfected children. Working with Prof S. Boppana and Deenan (laboratory component and Dr’s S. Knight and Ben Sartorius (epidemiologist) should be a rewarding experience. I am sure with the strength of having a comprehensive team would add to expected success of this project. I have no doubt that providing we are granted funding we would be able to share new and important data in the years to come. Hopefully our endeavors would result in less suffering of the children infected by HIV and CMV.
Position and honours
Career Employment Positions:
HEAD: Paediatric section -Respiratory unit KEH- 01/01/1994- 30/06/2002
Head: Paediatric Pulmonologist KEH/IALCH 01/02/1996- to Current
Head: ICU4 IALCH: 01/07/2002 to current
Associate Professor in Paediatrics: University of Kwazulu-Natal 01/07/2001 to current
1. Chairperson of an international data safety and monitoring board
BCG trial: randomized controlled trial comparing efficacy of percutanous and intradermal vaccination with Japanese (Tokyo) 172 BCG in the prevention od TB in infants vaccinated at birth P.I Prof G. Hussey AND Dr L. Geiter.
2. By minister of health as member of the national essential drug program of the country
3. President for the national asthma education 2001-2003. Congress and diploma course in asthma organizer in 2004- provision of course lectures and examinations
4. Chairperson of ministerial appointed subcommittee of essential drug program –hospital based paediatric book 2013
5. Appointed by the national minister of health as member of national advisory group for immunization 2005-2011 and co-opted in 2012
6. Advisor to the health directorate on PMTCT policy revision 2004-6.
7. WHO EXPERT ON ARI POLICY FOR HIV INFECTED CHILDREN – IN HARARE AND GENEVA 2003
8. Expert member on the WHO subcommittee for essential medicines in children
9. Advisor on vaccine related issues on the African continent
10. Ministerial invited expert on the national quarternary drug list committee of South Africa -2007 to current
11. International delegation developing guidelines for the management of acute respirations in childhood in Harare and Geneva under the guidance of the WHO.
12. Secretary for the South African Pulmonology Society-1998-2000
13. Member of the South African Asthma and Allergic Rhinitis working group
14. Head of Infectious disease at Clairwood Hospital 1993 to 2001.
15. Member of the task team draft national policy on paediatric critical care for South African children.
16. Editor/guest editor/chief editor
South African Respiratory Journal
South African Paediatric Reviews Journal
The Paediatric Quarterly Journal
The Paediatric Focus
1. Best senior presentation at the faculty research day 2004- Study on the care of HIV infected children with severe pneumonia
2. Best publication in critical care for 2005- Paper on utilization of scarce ICU resources in a developing world
3. Mary Weston research of the year 2005- University of Kwazulu Natal
List of Publications
Jeena PM. The management of adults and children with moderate severity asthma. SA Fam Pract 2007;49(4):28-34.
McNally LM, Jeena PM, Gajee K et al. Effect of age, polymicrobial disease, and Maternal HIV status on treatment responses and cause of severe pneumonia in South African children: a prospective descriptive study Impact of age, polymicrobial disease and maternal HIV status on response and aetiology of severe pneumonia in South African children. Lancet 2007 369: 1440-1451.
Jeena PM1, Minkara AK2, Corr P3, Bassa F3,McNally LM1, Coovadia HM1, Fox M4, Hamer DH4, Thea D4.Impact of HIV-1 status on the radiological presentation and clinical outcome of children with WHO defined community-acquired severe pneumonia treated with standardized WHO recommended antimicrobial therapy. Arch Dis Child. 2007; 92(11):976-9. Epub 2007 Jun 26.
Prendergast A, Tudor-Williams G, Jeena P, Burchett S, Goulder P. International perspectives, progress, and future challenges of paediatric HIV infection. Lancet 2007; 370 (9581) :68-80
Jeena PM. The interaction of HIV and tuberculosis in childhood. S Afr Med J. 2007 Oct;97(10 Pt 2):989-91.
Gie RP, Zar H, Jeena P, Beyers N. Childhood tuberculosis in South Africa–what is the present status? S Afr Med J. 2007 Oct;97(10 Pt 2):972.
Thobakgale CF, Ramduth D, Reddy S, Mkhwanazi N, de Pierres C, Moodley E, Mphatswe W, Blanckenberg N, Cengimbo A, Prendergast A, Tudor-Williams G, Dong K, Jeena P, Kindra G, Bobat R, Coovadia H, Kiepiela P, Walker BD, Goulder PJ. Human immunodeficiency virus-specific CD8+ T-cell activity is detectable from birth in the majority of in utero-infected infants.J Virol. 2007 Dec;81(23):12775-84. Epub 2007 Sep 19.
Mphatswe W, Blanckenberg N, Tudor-Williams G, Jeena P et al Rapid immunological deterioration in African infants infected following perinatal HIV propylaxis following nevirapine monotherapy to prevent mother to child transmission (accepted –AIDS)
Maharaj SS, Jeena PM. Cycle ergometer and rebound exercise with chest physiotherapy- a useful adjunct for sputum expectoration in mild to moderately symptomatic HIV infected children. SA J. Physiotherapy 2008;64: 37-42
Jeena PM. Vaccines, immunization and HIV Infection- South African Journal of Child Health 2008
Jeena PM, Adhikari M, Carlin JB, Qazi S, Weber mw, Hamer D. Clinical profile and predictors of severe illness in young South African infants SAMJ 2008.
Hawkridge A, Hatherill M, Little F, Goetz MA, Barker L, Mahomed H, Sadoff J, Hanekom W, Geiter L, Hussey G; South African BCG trial team. Efficacy of percutaneous versus intradermal BCG in the prevention of tuberculosis in South African infants: randomised trial. BMJ. 2008 Nov 13;337:a2052. doi: 10.1136/bmj.a2052
Patel A, Mamtani M, Hibberd PL, Tuan TA, Jeena P, Chisaka N, Hassan M, Maulen-Radovan I, Thea DM, Qazi S, Kulkarni H. Value of chest radiography in predicting treatment response in children aged 3-59 months with severe pneumonia Int J Tuberc Lung Dis. 2008;12(11):1320-6.
Jeena PM. Can the burden of pneumonia among HIV-infected children be reduced? Bull World Health Organ. 2008 May;86(5):323-3A. No abstract available.
Jeena PM, Bobat B, Thula SA, Adhikari M. Children with Pneumocystis jiroveci pneumonia and acute hypoxaemic respiratory failure admitted to a PICU, Durban, South Africa. Arch Dis Child. 2008 Jun;93(6):545.
Ramduth D, Thobakgale CF, Mkhwanazi NP, De Pierres C, Reddy S, van der Stok M, Mncube Z, Mphatswe W, Blanckenberg N, Cengimbo A, Prendergast A, Tudor-Williams G, Dong K, Jeena P, Coovadia HM, Day CL, Kiepiela P, Goulder PJ, Walker BD. Detection of HIV type 1 gag-specific CD4(+) T cell responses in acutely infected infants. AIDS Res Hum Retroviruses. 2008 Feb;24(2):265-70.
Thobakgale C, Jeena PM. Impact of hla in mother and child on paediatric hiv-1 disease progression 2009(jvi00921-09)
Bobat R; Kindra G; Kiepiela P; Reddy S; Jeena PM; Adhikari M; Coovadia HM. Use of Abacavir in 30 HIV-infected children from Durban, South Africa- report from a pilot study. Ped Infect Dis J. 2010; 9: 890
Green RJ, Zar HJ, Jeena PM, Madhi SA, Lewis H. South African guideline for the diagnosis, management and prevention of acute viral bronchiolitis in children S. Afr Med J 2010; 100: 320-325
Jeena P. “HIV-Associated Tuberculosis in the Newborn and Young Infant,” International Journal of Pediatrics, vol. 2011, Article ID 354208, 10 pages, 2011. doi:10.1155/2011/354208.
Singh R, Thula SA, Jeena PM. Lung infiltrates in antiretroviral-naïve HIV infected children with chronic lung disease: value of non bronchoscopic bronchoalveolar lavage in the detection of candida albicans. J Trop. Pediatr. 2013: 1: 59-63.
Jeena PM. Reichart K, Adhikari M et al. Clinical manifestations and outcome in HIV- INFECTED YOUNG INFANTS presenting with acute illness in Durban South Africa. Ann Trop paediatr. 2012; 31(1): 15-26.
Jeena PM, Bishai WR, Pasipanodya JG, Gumbo T. In silico children and the glass mouse model: clinical trial simulatiomns to identify and individualise optimal isoniazid doses in children with tuberculosis. Antimicrob Agents Chemother. 2011; 55(2): 539-45.
Green R, Morrow B, Argent AC, Jeena P. Linezolid dosing for Staphlococcal pneumonia in children. South Afr med J 2009; 99(11)770-2.
Kling S, Zar HJ, Levin ME, Green RJ, Jeena PM et al. Guidelines for the management of acute asthma in 2013: update 2013. S. Afr. Med J. 2013;103: 199-207.
Shaik J, Pillay M Jeena P. The role of interferon gamma release assays in the monitoring of response to antituberculosis treatment in children. Paediatr Respir Rev. 2013; 11: s1526-42.
Izadnegahdar R, Fox MP, Jeena P, Qazi S, Thea D. Revisiting pneumonia and exposure status in infants born to HIV-INFECTED mothers. Pediatr Infect Dis J2014; 33(1): 70-2.
Masekela R, Gray D, Verwey C, Halkas A, Jeena PM. Paediatric spirometry guideline of the South African Thoracic Society Part 1. S. Afr Med J 2013 103(12):1036-41
Green R, Jeena P, Kotze S, Lewis H, Webb D, Wells M. Management of acute fever in children: guideline for community health care providers and pharmacists. S Afr Med J 2013;103(12): 948-54.
Dimitriades K, Morrow BM, Jeena PM. A retrospective study on the effects of colistin therapy in children with multidrug resistant Gram-negative bacterial pneumonia: impact of HIV status on outcome. Arch. Dis Child 2014;99(3):262-6.
Schaaf HS, Cotton MF, Boon GP, JeenaPM. Isoniazid preventative therapy in HIV infected and uninfected children (0-14years). S Afr Med J. 2013;103(10):714-5.